EWS/FLI 1 Type 8

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** An antisense oligonucleotide that targets the type 8 form of EWS/FLI-1, an oncogenic fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumor that results from a t(11;22) chromosomal translocation. EWS/FLI 1 type 8 antisense oligonucleotide inhibits the expression of the EWS/FLI 1 type 8 gene and/or the translation of EWS/FLI 1 type 8 mRNA, thereby down-regulating the abnormal transcription factor and inhibiting tumor cell growth and tumorigenicity. (NCI04)

**Synonyms:** - Sarcoma-specific Peptide SSSYGQQN/PYQILGPTSS