Hydrazine

**Semantic type:** Pharmacologic Substance

**Definition:** A highly reactive base and reducing agent used in many industrial and medical applications. In biological applications, hydrazine and its derivatives exhibit antidepressant properties by inhibiting monoamine oxidase (MAO), an enzyme that catalyzes the deamination and inactivation of certain stimulatory neurotransmitters such as norepinephrine and dopamine. In psychiatry, the use of hydrazine derivatives is limited due to the emergence of the tricyclic antidepressants. (NCI04)

**Synonyms:** - HYDRAZINE