Imexon

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. (NCI04)

**Synonyms:** - 4-imino-1,3-diazabicyclo[3,1,0]-hexan-2-one - Amplimexon - Amplimexon - IMEXON - imexon