M A T101 HUMAN T-LYMPHOCYTE

**Semantic type:** Pharmacologic Substance

**Definition:** A murine monoclonal antibody (also known as T101) directed against T65, an antigen found on cutaneous T cell lymphoma (CTCL) cells and chronic lymphocytic leukemia (CLL) cells as well as normal T lymphocytes. M A T101 human T-lymphocyte binds to T cells that express T65, potentially promoting their removal from the circulation, and may induce a cytotoxic T-cell response against T65-expressing T-cells. This agent may also be conjugated to toxins such as ricin for targeted delivery to T65-expressing T cells. (NCI04)