Monoclonal Antibody 48.7 F(ab)

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A Fab fragment of the mouse monoclonal antibody (MoAb) 48.7. MoAb 48.7 Fab (fragment antigen binding) recognizes proteoglycan antigen expressed on the cell surface of melanoma cells. The Fab fragments are obtained through papain digestion in the presence of cysteine. The advantage of using MoAb 48.7 Fab fragments over whole antibodies is that they have reduced immunogenicity, better penetration of tissues, rapid clearance from the body and that they do not induce precipitation.

**Synonyms:** - MOAB 48.7 FAB