Monoclonal Antibody 2A11

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A recombinant, murine monoclonal antibody directed against gastrin-releasing peptide, one of a number of bombesin-like peptides (BLP). Tumor cells, such as small cell lung cancer (SCLC) cells, express and secrete BLP that activate specific cell growth-promoting receptors. Monoclonal antibody 2A11 has been shown to decrease the growth of SCLC cells in vitro and in animal models. (NCI04)

**Synonyms:** - MOAB Bombesin