Monoclonal Antibody RG 83852

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A murine monoclonal antibody directed against the human epidermal growth factor receptor (EGFR). Monoclonal antibody RG 83852 binds to the EGFR, inhibiting the high-affinity binding of epidermal growth factor (EGF) and receptor activation. Overexpression of EGFR, a tyrosine kinase, and its upregulated activity have been implicated in the pathogeneses of several malignancies. (NCI04)

**Synonyms:** - MOAB RG 83852