Nitrofurantoin

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic derivative of imidazolidinedione, Nitrofurantoin inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections. (NCI04)

**Synonyms:** - Macrobid - Macrodantin - NITROFURANTOIN