Oxaprozin

**Semantic type:** Pharmacologic Substance

**Definition:** A nonsteroidal anti-inflammatory drug (NSAID) derivative of oxazole-propionic acid with analgesic and antipyretic properties. As a first generation NSAID inhibitor, oxaprozin binds to and inactivates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory prostaglandins. When inhibiting COX-2, this agent may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. (NCI04)

**Synonyms:** - 4,5-Diphenyl-2-oxazolepropionic Acid - Daypro - OXAPROZIN - Wy 21743