Pentamidine Isethionate

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent that appears to interact with the minor groove of AT-rich DNA regions of the pathogen genome, interfering with DNA replication and function. It is effective in the treatment of trypanosomiasis, leishmaniasis, some fungal infections, and Pneumocystis carinii pneumonia in HIV-infected patients. (NCI04)

**Synonyms:** - PENTAMIDINE DIISETHIONATE - Pentacarinat - Pentam - Pentam - Pentamidine Diisethionate - pentamidine isethionate