Pimonidazole Hydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The hydrochloride salt form of pimonidazole, a hypoxia-selective 2-nitroimidazole with potential radiosensitizing activity. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic cells and tumors, reduced pimonidazole binds to thiol-containing proteins and glutathione. The resulting complexes accumulate in hypoxic tumors, deplete radioprotective thiol compounds, and cause the tumor to be more susceptible to radiation treatment.

**Synonyms:** - 1-Piperidineethanol, Alpha-((2-nitro-1H-imidazol-1-yl)methyl)-, Monohydrochloride - PIMONIDAZOLE HYDROCHLORIDE