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C29372Level 5

Potassium Citrate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The potassium salt form of citrate, with alkalinizing activity and that can be used for potassium supplementation. Upon oral administration, potassium citrate provides potassium. Potassium maintains normal fluid and electrolyte balance, regulates the proper functioning of heart and muscle contractions, supports healthy bone density and blood pressure. It also plays an important role in the transmission of nerve impulses and energy production. Amino acid chelated minerals are highly bioavailable and better absorbed than non-amino acid-chelated minerals. Potassium citrate also causes increased plasma bicarbonate concentration, thereby raising blood and urinary pH. A simultaneous decrease in calcium ion activity occurs as a result of increasing calcium complex formation with dissociated anions. Levels of urinary citrate are increased due to modification of the renal handling of citrate. By promoting excretion of free bicarbonate ion and by increasing urinary pH in addition to an increased ionization of uric acid to more soluble urate ions, this agent exerts alkalizing and anti-urolithic effect.

**Synonyms:** - 2-Hydroxy-1,2,3-propanetricarboxylic Acid, Potassium Salt - 2-Hydroxy-1,2,3-propanetricarboxylic Acid, Potassium Salt - POTASSIUM CITRATE - Potassium Citrate Monohydrate - Potassium Complex

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