Quinine Sulfate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

**Synonyms:** - Chininum Sulphuricum - Cinchonan-9-ol, 6'-methoxy-, (8 alpha,9R)-, Sulfate, Hydrate (2:1:2) - QUININE SULFATE - Qualaquin