Recombinant Vaccinia-MUC1-B7 Vaccine

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** An admixture of recombinant vaccinia virus encoding MUC-1 and recombinant vaccinia virus encoding the murine T-cell co-stimulatory molecule B7.1. MUC-1 is a glycosylated mucin that is overexpressed in breast, lung, pancreatic, prostate, stomach, colon, and ovarian carcinomas. Vaccination with MUC-1 in combination with B7.1 may enhance the cytotoxic T cell (CTL) immune response to tumors expressing MUC-1, compared to vaccination with MUC-1 alone. (NCI04)

**Synonyms:** - MUC1-B7-Vaccinia Vaccine - Recombinant Vaccinia-MUC1-B7.1 - rV-MUC1-B7.1