Zolimomab Aritox

**Semantic type:** Pharmacologic Substance

**Definition:** An immunotoxin consisting of a murine anti-CD5 monoclonal antibody conjugated to the ricin A chain. The anti-CD5 monoclonal antibody component binds to CD5, a T-cell associated antigen, thereby targeting the delivery of the cytotoxic ricin A chain to T-cells. The ricin A chain component binds to T-cells and disrupts ribosomal activity and protein synthesis and induces cell cycle arrest. (NCI04)

**Synonyms:** - Anti-CD5 MoAb - Anti-CD5 T-Lymphocyte Immunotoxin - Anti-T-Cell RTA Immunotoxin - Anti-T-Cell Ricin A Chain Immunotoxin - CD5-Immunoconjugate - H65-RTA - Immunoglobulin G 1 (Mouse Monoclonal H65-RTA Anti-human Antigen CD 5 Heavy Chain), Disulfide with Mouse Monoclonal H65-RTA Light Chain, Dimer, Disulfide with Ricin (Castor-oil Plant A-chain Protein Moiety) - Orthozyme-CD5 Plus - XomaZyme-CD5 Plus - ZOLIMOMAB ARITOX