Recombinant Vaccinia-PSA(L155)-TRICOM Vaccine

**Semantic type:** Pharmacologic Substance|Virus

**Definition:** A recombinant vaccinia virus encoding a modified peptide of the prostate-specific antigen (PSA) with a leucine substitution at position 155, and a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3). Vaccination with this viral vaccine may enhance antigen presentation and may activate cytotoxic T-cells against PSA-expressing tumor cells.

**Synonyms:** - PROSTVAC-V/TRICOM - Recombinant Vaccinia-PSA(L155)/TRICOM - rVaccinia-PSA(L155)-TRICOM Vaccine