Recombinant Vaccinia-Tyrosinase

**Semantic type:** Pharmacologic Substance|Virus

**Definition:** A recombinant vaccinia virus (based on the modified vaccinia virus Ankara) expressing tyrosinase. Tyrosinase is a melanoma-specific differentiation agent that catalyzes the synthesis of the melanin precursor dihydroxyphenylalanine (DOPA). Vaccination with this agent may evoke a melanoma-specific T-cell response.

**Synonyms:** - rV-TYR