Basal Transcription Factor Gene

**Semantic type:** Gene or Genome

**Definition:** Human Basal Transcription Factor Genes encode Basal Transcription Factors, a diverse group of general factors required for transcription of all eukaryotic PolII genes. Initiation of transcription from eukaryotic protein-coding genes is a complex process requiring RNA polymerase II (PolII) and a cadre of transcription factors. The general transcription factors and PolII form a multiprotein complex near the transcription start site by interacting with core promoter elements. The most common core element is the TATA box, typically 25-30 bp upstream of the start site.

**Synonyms:** - General Transcription Factor Gene