Gamma Heavy Chain Disease

**Semantic type:** Neoplastic Process

**Definition:** A clonal disorder characterized by the secretion of a truncated gamma chain. In most cases, it is associated with morphologic changes also seen in lymphoplasmacytic lymphomas, but the clinical course is typically more aggressive than in lymphoplasmacytic lymphoma.

**Synonyms:** - Franklin Disease - Franklin disease - Franklin's Disease - Gamma heavy chain disease