Dicumarol

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicumarol is a competitive inhibitor of vitamin K epoxide reductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.

**Synonyms:** - 3,3'-Methylenebis(4-hydroxy-2H-1-benzopyran-2-one) - Bishydroxycoumarin - Bishydroxycoumarin - DICUMAROL - Dicoumarol - Dicoumarol