Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

**Semantic type:** Neoplastic Process

**Definition:** A phase of chronic myeloid leukemia characterized by one or more of the following: 1) Myeloblasts accounting for 10-19% of the peripheral blood white cells or of the nucleated cells in the bone marrow, 2) peripheral blood basophils at least 20%, 3) persistent thrombocytopenia that is unrelated to therapy, 4) persistent thrombocytosis despite adequate therapy, 5) increasing white blood cell count and increasing spleen size unresponsive to therapy, and/or evidence of clonal evolution. (WHO, 2001)

**Synonyms:** - Accelerated Phase CML - Accelerated Phase Chronic Granulocytic Leukemia - Accelerated Phase Chronic Myelocytic Leukemia - Accelerated Phase Chronic Myelogenous Leukemia - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive - Accelerated Phase Chronic Myelogenous Leukemia, BCR::ABL1 Positive - Accelerated Phase Chronic Myeloid Leukemia - Accelerated Phase Chronic Myeloid Leukemia, BCR::ABL1 Positive - Aggressive-Phase CML - Aggressive-Phase Chronic Myelocytic Leukemia - Aggressive-Phase Chronic Myelogenous Leukemia - Aggressive-Phase Chronic Myeloid Leukemia - accelerated phase chronic myelogenous leukemia