Stratum Corneum

**Semantic type:** Anatomical Structure

**Definition:** The most superficial layer of the epidermis and the surface coating of the skin, primarily consisting of layers of corneocytes, which are dead, flat, enucleated, keratin-filled cells. The stratum corneum serves as a physiological barrier for the protection of underlying tissues, as well as a barrier to fluid and solute loss from within the body.

**Synonyms:** - Horny Layer