Annona muricata

**Semantic type:** Plant

**Definition:** A common name for the tropical tree Annona muricata whose tissues contain annonaceous acetogenins, compounds with antineoplastic activity. Annonaceous acetogenins, derivatives of long-chain fatty acids, exhibit their anti-tumor properties by depleting cellular stores of adenosine 5'-triphosphate (ATP), a primary source of energy in cells. These agents also inhibit ATP-driven drug resistance mechanisms. Possessing a broad range of therapeutic activities, graviola has been used in different cultures for its pesticidal, antifungal,, antispasmodic, anticonvulsant, vasodilator, smooth-muscle relaxant, and hypotensive properties. (NCI04)

**Synonyms:** - ANNONA MURICATA WHOLE - Brazilian Cherimoya - Brazilian Paw Paw - Graviola - Guanabana - Prickly Custard Apple - Soursop