RBP2-Like Protein

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Widely expressed by human PLU-1 Gene (RBBP Family) at varying levels (highest in Sertoli cells), 1544-aa 176-kDa nuclear RBP2-Like Protein contains 3 Cys-rich zinc-binding DNA-binding PHD/LAP domains, a DNA-binding dead ringer domain, 5 putative nuclear localization signals, a putative DNA/chromatin binding motif, and other conserved regions of unknown function. With an additional 137 amino acids, 1681-aa 190-kDa RBBP2H1A appears to be an alternate PLU-1 product that shares 56% overall amino acid sequence identity with RBBP2, important in RB tumor suppressor regulation. (NCI)

**Synonyms:** - AT Rich Interactive Domain 1B Protein - JARID1B - Jumonji Protein - PLU-1 - PLU-1 Protein - PUT1 - RBBP2H1A - Retinoblastoma-Binding Protein 2 Homolog 1A