Carbenicillin

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.

**Synonyms:** - CARBENICILLIN - CARBENICILLIN - Geopen - Geopen - Pyopen - Pyopen