Glucarpidase

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor.

**Synonyms:** - Acetylaspartylglutamate Dipeptidase - CPDG2 - CPG2 - Carboxypeptidase G2 - GLUCARPIDASE - Megludase - Poly(gamma-glutamic Acid) Endohydrolase - Pteroylpolygammaglutamyl Hydrolase - Voraxaze - carboxypeptidase-G2