Grade 4 Clear Cell Renal Cell Carcinoma

**Semantic type:** Neoplastic Process

**Definition:** A clear cell renal cell carcinoma characterized by extreme nuclear pleomorphism and/or sarcomatoid and/or rhabdoid differentiation and/or tumor giant cells. (WHO, 1982 /ISUP 2014)

**Synonyms:** - G4 Nuclei bizarre and multilobated, 20 um or greater, nucleoli prominent, chromatin clumped - Grade 4 Conventional (Clear Cell) Renal Cell Carcinoma