t(8;14)(q24;q32)

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A chromosomal translocation that fuses 8q24 with 14q32. This juxtaposes the MYC gene with the promoter regions of the immunoglobulin heavy chain gene locus, which results in overexpression of Myc proto-oncogene protein in B-cells bearing the translocation.