Clonal Gene Rearrangement

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A DNA sequence rearrangement that results in the creation of novel immunoglobulins and T-cell receptors expressed by lymphocytes. This process occurs very early in the differentiation of B- and T-lymphocytes, such that individual B- and T-cell progenitors have unique genetic profiles that are passed down to their descendants. This leads to clonal populations of lymphocytes expressing the unique proteins selected during maturation.

**Synonyms:** - Monoclonal Gene Rearrangement