t(1;22)(p13.3;q13.1)

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A cytogenetic abnormality that refers to the translocation of the short arm (p13.3) of chromosome 1 and the long arm (q13.1) of chromosome 22. It is associated with RBM15/MRTFA (MKL1) fusions and acute megakaryocytic leukemia.

**Synonyms:** - t(1;22)(p13;q13)