t(1;2)(p22;p12)

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A chromosomal translocation involving breakpoints within the p22 band on the short arm of chromosome 1 and the p12 band on the short arm of chromosome 2. This rearrangement is associated with aberrant expression of mutated forms of the BCL10 gene and extranodal mucosa-associated lymphoid tissue (MALT) lymphoma.