t(5;21)(q13;q22)

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A chromosomal translocation involving breakpoints within the q13 band on the long arm of chromosome 5 and the q22 band on the long arm of chromosome 21. This rearrangement may be associated with aberrant expression of the RUNX1 gene and myelodysplastic syndrome and/or acute myeloid leukemia.