Inactivating MSH2 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the MSH2 gene that either inhibits expression or results in the translation of an inactive DNA mismatch repair protein Msh2 protein.

**Synonyms:** - Inactivating MSH2 Mutation - Loss of Function COCA1 Gene Mutation - Loss of Function HNPCC Gene Mutation - Loss of Function HNPCC1 Gene Mutation - Loss of Function MSH2 Mutation - Loss of Function MutS Homolog 2 Gene Mutation - Loss of Function MutS, E. coli, Homolog of, 2 Gene Mutation - MSH2 Gene Inactivation - MSH2 Loss of Function Gene Mutation - MSH2 Loss of Function Mutation - hMSH2 Mismatch Repair Gene Inactivation