Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation

**Semantic type:** Neoplastic Process

**Definition:** Chronic lymphocytic leukemia characterized by the presence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a better prognosis as compared to those with unmutated immunoglobulin heavy chain gene variable region rearrangements.

**Synonyms:** - CLL with IGVH SHM - Postgerminal Center Chronic Lymphocytic Leukemia