Zebularine

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions.

**Synonyms:** - 1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone - 2-Pyrimidone-1-beta-D-riboside - 4-Deoxyuridine - Pyrimidin-2-one beta-Ribofuranoside - ZEBULARINE