Cisplatin

**Semantic type:** Inorganic Chemical|Pharmacologic Substance

**Definition:** An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.

**Synonyms:** - (SP-4-2)-Diamminedichloroplatinum - Abiplatin - Blastolem - Briplatin - CDDP - CISPLATIN - Cis-diammine-dichloroplatinum - Cis-diamminedichloridoplatinum - Cis-diamminedichloro Platinum (II) - Cis-diamminedichloroplatinum - Cis-dichloroammine Platinum (II) - Cis-platinous Diamine Dichloride - Cis-platinum - Cis-platinum II - Cis-platinum II Diamine Dichloride - Cismaplat - Cisplatina - Cisplatinum - Cisplatyl - Citoplatino - Citosin - Cysplatyna - DDP - Lederplatin - Metaplatin - Neoplatin - Peyrone's Chloride - Peyrone's Salt - Placis - Plastistil - Platamine - Platiblastin - Platiblastin - Platiblastin-S - Platinex - Platinol - Platinol - Platinol- AQ - Platinol-AQ - Platinol-AQ VHA Plus - Platinoxan - Platinum - Platinum Diamminodichloride - Platinum, Diaminedichloro-, cis- (8CI) - Platiran - Platistin - Platosin - cisplatin