Clofibrate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An aryloxyisobutyric acid derivate with antihyperlipidemic activity. Although the exact mechanism of action has not been fully characterized, clofibrate may enhance the conversion of very-low-density lipoprotein (VLDL) to low-density lipoprotein (LDL), decreasing the production of hepatic VLDL, inhibiting cholesterol production, and increasing fecal excretion of neutral sterols.

**Synonyms:** - 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester - Atromid S - Atromid-S - Atromid-S - CFB - CLOFIBRATE - Ethyl 2-(4-Chlorophenoxy)-2-methylpropanoate - Ethyl p-Chlorophenoxyisobyturate