Murine Monoclonal Antibody 225

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A mouse monoclonal antibody that was raised against human epidermal growth factor (EGF) receptor. Antibody 225 competes with EGF or transforming growth factor-alpha (TGF alpha) for receptor binding and thereby prevents ligand-induced receptor tyrosine kinase activation resulting in the inhibition of proliferation of human cancer cells that are stimulated by the TGFalpha/EGF receptor autocrine loop.

**Synonyms:** - Anti-EGF Receptor IgG1(Hybritech)