6-Aminonicotinamide

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04)

**Synonyms:** - 6-AMINONICOTINAMIDE - 6-AN - Aminonicotinamide - U-8774