Methionine Aminopeptidase 2 Inhibitor PPI-2458

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. (NCI04)

**Synonyms:** - MetAP-2 Inhibitor PPI-2458 - PPI-2458 - PPI-2458