Buccal Route of Administration

**Semantic type:** Functional Concept

**Definition:** Administration of a substance through the mucosal membrane on the inside of the cheek or the back of the mouth. Buccal route bypasses first pass metabolism and avoids pre-systemic elimination in the gastrointestinal tract. The buccal environment is well supplied with both vascular and lymphatic drainage and is well suited for a retentive device. This is a feasible alternative for systemic delivery of orally inefficient drugs, such as peptide and protein drug molecules.

**Synonyms:** - BUCC - BUCCAL - BUCCAL - BUCCAL - BUCCAL - Buccal - Buccal - Buccal use