Nitric Oxide Synthase 2B

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Encoded by human NOS2B Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2B binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2B may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)

**Synonyms:** - NOS Type IIB - NOS2B - NOSIIB - Nitric Oxide Synthase IIB