Amsilarotene

**Semantic type:** Pharmacologic Substance

**Definition:** A retinobenzoic acid with potential antineoplastic activity. Amsilarotene inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression.

**Synonyms:** - AMSILAROTENE - TAC 101 - TAC-101 - TAC-101