Muparfostat

**Semantic type:** Pharmacologic Substance

**Definition:** A mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic activity. Muparfostat inhibits the endo-beta-D-glucuronidase heparanase, which may interfere with the heparanase-mediated degradation of heparan-sulfate proteoglycans in extracellular matrices, an important step in the metastatic process. This agent may also bind with high affinity to the heparan sulfate-binding domains of vascular endothelial growth factor (VEGF) and fibroblast growth factors 1 and 2, thereby reducing their functional activities and inhibiting VEGF and FGF stimulation of tumor angiogenesis. Increased heparanase activity has been implicated in tumor angiogenesis and metastasis.

**Synonyms:** - 6-O-(dihydrogen Phosphate)-2,3,4-tris-O-(hydrogen Sulfate)-alpha-d-mannopyranosyl-(1->poly(3)-2,4,6-tris-O-(hydrogen Sulfate)-alpha-d-mannopyranosyl-(1->)2)-1,3,4,6-tetrakis-O-(hydrogen Sulfate)-d-mannopyranose - MUPARFOSTAT - PI 88 - PI-88 - PI-88 - Phosphomannopentose Sulfate PI-88 - Sulfated Phosphomanno-oligosaccharide PI-88 - alpha-D-Mannan, (1->3)-, 6-(Dihydrogen Phosphate) Tris(Hydrogen Sulfate)