Pertuzumab

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04)

**Synonyms:** - 2C4 - 2C4 Antibody - BCD-178 - EG1206A - HLX11 - HS627 - Immunoglobulin G1, Anti-(Human V (Receptor)) (Human-Mouse Monoclonal 2C4 Heavy Chain), Disulfide with Human-Mouse Monoclonal 2C4 Kappa-Chain, Dimer - MoAb 2C4 - Monoclonal Antibody 2C4 - Omnitarg - PERTUZUMAB - Perjeta - Pertuzumab Biosimilar BCD-178 - Pertuzumab Biosimilar EG1206A - Pertuzumab Biosimilar HLX11 - Pertuzumab Biosimilar HS627 - Pertuzumab Biosimilar TQB2440 - Pertuzumab-dpzb - Poherdy - RO4368451 - Rhumab 2C4 - TQB 2440 - TQB-2440 - TQB2440 - pertuzumab - rhuMAb2C4