Lamotrigine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)

**Synonyms:** - LAMOTRIGINE - Lamictal - lamotrigine