Thyroid Gland Medullary Carcinoma

**Semantic type:** Neoplastic Process

**Definition:** A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy.

**Synonyms:** - C Cell Carcinoma - C Cell Carcinoma - C Cell Carcinoma - C cell carcinoma - C-Cell Carcinoma - CARCINOMA, C-CELL, MALIGNANT - MTC - MTC - Medullary Carcinoma - Medullary Carcinoma - Medullary Carcinoma of Thyroid - Medullary Carcinoma of Thyroid - Medullary Carcinoma of Thyroid Gland - Medullary Carcinoma of Thyroid Gland - Medullary Carcinoma of the Thyroid - Medullary Carcinoma of the Thyroid - Medullary Carcinoma of the Thyroid Gland - Medullary Carcinoma of the Thyroid Gland - Medullary Thyroid Cancer - Medullary Thyroid Cancer - Medullary Thyroid Carcinoma - Medullary Thyroid Carcinoma - Medullary Thyroid Carcinoma - Medullary Thyroid Gland Carcinoma - Medullary Thyroid Gland Carcinoma - Medullary thyroid carcinoma - Parafollicular Cell Carcinoma - Parafollicular Cell Carcinoma - Parafollicular cell carcinoma - Thyroid Gland Medullary Cancer - Thyroid Gland Neuroendocrine Carcinoma - Thyroid Gland Neuroendocrine Carcinoma - Thyroid Medullary Carcinoma - Thyroid Medullary Carcinoma - medullary thyroid cancer