Interleukin 12 Receptor

**Semantic type:** Amino Acid, Peptide, or Protein|Receptor

**Definition:** Human high affinity Interleukin 12 Receptor is composed of Interleukin 12 Receptor Beta 1 Chain (I12RB1) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2), each a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in IL12 signal transduction, IL12RB1 and IL12RB2 oligomers act as low affinity IL12 receptors. (NCI)

**Synonyms:** - High Affinity Interleukin 12 Receptor - High Affinity Interleukin 12 Receptor Beta - IL-12R - IL12R - INTERLEUKIN-12 RECEPTOR - Interleukin 12 Receptor Beta - Interleukin-12 Receptor