Chronic Lymphoproliferative Disorder of NK-Cells

**Semantic type:** Neoplastic Process

**Definition:** An Epstein-Barr virus negative disorder with a chronic clinical course affecting predominantly adults and characterized by the proliferation of large granular lymphocytes with natural killer cell immunophenotype. The T-cell receptor genes are not rearranged.

**Synonyms:** - CLPD-NK - Chronic NK-Cell Lymphocytosis - Chronic NK-LGL Lymphoproliferative Disorder - Chronic NK-Large Granular Lymphocyte Lymphoproliferative Disorder - Chronic lymphoproliferative disorder of NK cells - Indolent Large Granular NK-Cell Lymphoproliferative Disorder - Indolent NK-Cell Lymphoproliferative Disorder - NK Large Granular Lymphocytic Leukemia - NK-Cell Large Granular Lymphocyte Lymphocytosis - NK-LGL leukemia - NK-LGLL - NK-Large Granular Lymphocytic Leukemia - NK-Type Lymphoproliferative Disorder of Granular Lymphocytes - natural killer-cell large granular lymphocyte leukemia