DN-101

**Semantic type:** Pharmacologic Substance

**Definition:** An oral high dose formulation of calcitriol, the biologically active form of Vitamin D. Acting as a ligand for the Vitamin D receptor (VDR), DN-101 binds to the VDR inhibiting VDR-regulated gene transcription involved in cell proliferation, differentiation and apoptosis. (NCI)

**Synonyms:** - Ro 21-5535